Circadian Rythm and Drug Effectiveness

May 15, 2024

A new study by MIT researchers published in Science Advances suggests that the effectiveness and toxicity of drugs can vary significantly based on the time of day they are administered. This variation is due to circadian rhythms in liver function, which influence how drugs are metabolized. By studying engineered mini-livers that mimic human liver functions, the team discovered that many genes involved in drug metabolism exhibit circadian control. These findings indicate that timing drug administration to align with these rhythms could enhance drug efficacy and reduce side effects. This research could lead to improved dosing schedules for a range of medications, potentially transforming how we approach treatment for various conditions.

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